Peptides: The Wave of the Future
نویسندگان
چکیده
Introduction To investigate the conformational changes associated with photoactivation of rhodopsin [1], the GPCR of vision, we have embarked on a program of chemical synthesis of its transmembrane segments. By reconstituting such synthetic segments containing specific fluorescent and spin labels with expressed segments of rhodopsin, we hope to generate hybrid “split receptors” that are fully functionally for biophysical studies. For this reason, a number of TM fragments of rhodopsin were synthesized by various solid-phase protocols, and chemical ligation was used to link these fragments into larger fragments of rhodopsin.
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